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CWT-004 for Wound Healing

As we get older, our capacity for skin healing becomes impaired, representing a significant unmet clinical need and a barrier to healthy ageing. The incidence of non-healing skin wounds is estimated to be more than 5-7million in the US alone, costing over $25 Billion per year to treat [1]. To target this Causeway, in partnership with Dr Andrea Caporali at the University of Edinburgh, is developing a miR-148b replacement therapy. Work published by Dr Caporali’s group showed that wounds treated with miR-148b healed faster and more completely compared to placebo controls [2]. A miR-148b based therapy has the potential to enhance the healing of diabetic foot ulcers but also wounds more generally. 
1. Sen, C.K., et al. (2009) Human skin wounds: A major and snowballing threat to public health and the economy. Wound Repair Regen. 17(6):763–771
2. Miscianinov, V. et al. (2018). MicroRNA-148b Targets the TGF-β Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing. Molecular Therapy. 26 (8), p1-12.
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Causeway Therapeutics
Imaging Centre of Excellence Building
Queen Elizabeth University Hospital
Glasgow, G51 4TF
 
Office  +44 141 451 6824
  • Home
  • About
    • About Us
    • Our Mission
    • Our Technology
  • Team
    • Leadership
    • Board
    • Advisors
  • Programs
    • Pipeline
    • Tendinopathy
    • Osteoarthritis
    • Intervertebral disc disease
    • Skin Ageing
    • Wound Healing
  • Publications
  • Animal Health
  • News
  • Careers
  • Investors
  • Contact